The Centre for Clinical Genomics (CCG) is pleased to announce its 14 gene Hereditary Cancer Program Panel is now available to patients across Canada. This panel replaced BRCA1/2 testing in British Columbia in October 2014.
|BRCA1||Hereditary Breast/Ovarian Cancer|
|PTEN||PTEN Harmartoma Tumour Syndrome|
|CDH1||Hereditary Diffuse Gastric Cancer|
|APC||Familial Adenomatous Polyposis|
MLPA for copy number changes is offered for BRCA1, BRCA2, MLH1 and MSH2 upon request.
In British Columbia: Referrals for this assay must be requested through the BC Cancer Agency Hereditary Cancer Program.
Outside British Columbia: please contact us for details and requisition forms.
The current turnaround time is 8-10 weeks. A list of ACMG 1, 2, and 3 variants with clinical interpretation will be reported by the Cancer Genetics Laboratory.
We are offering the 14 gene panel at the same cost as simply testing BRCA1/2. Please contact us for further details.
Variants in exons 5, 11, 12, 13, 14, and 15 of PMS2 are not reported.
The development of the BRCA1/2 assay is described in Bosdet et al. 2013.